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"The rise of civilization lesson quiz 1-3" which statement is most acurate A. The flooding of the Tigris and Euphrates was the main factor that led to civilization in Mesopotamia B. The melting of snows in the upland mountains was the main factor that led to civilization in Mesopotamia C. Irrigation and drainage ditches were the main factors that led to civilization in Mesopotamia D. The flooding of the Tigris and Euphrates and the ability to control were the main factors that led to civilization in mespotamia