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Why did Isaac Newton's university closed

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Because, In 1665, he discovered the generalised binomial theorem and began to develop a mathematical theory that later became infinitesimal calculus. Soon after Newton had obtained his degree in August 1665, the University closed down as a precaution against the Great Plague of London.
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Isaac Newton closed his university because of an outbreak of the bubonic plague in England, making Cambridge University close its doors, forcing Newton to return home to Woolsthorpe Manor.

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