Answered

Welcome to Westonci.ca, the place where your questions are answered by a community of knowledgeable contributors. Ask your questions and receive detailed answers from professionals with extensive experience in various fields. Experience the convenience of finding accurate answers to your questions from knowledgeable experts on our platform.

Thymine in DNA occurs as the result of thymidylate synthase creating _______, which then undergoes _______ to _______, then to _______, and incorporated into D N A by _______. Thymine in tRNA arises ________, by an S-adenosylmethionine-dependent _______ of a ______ residue in RNA.
a. UMP
b. translocation
c. post-translationally
d. dTDP
e. post- transcriptionally
f. hydroxylation
g. DNA synthase
h. phosphorylation
i. methylation
j. GMP
e. CMP

Sagot :

luisvaschetto

Answer:

Thymine in DNA occurs as the result of thymidylate synthase creating deoxythymidine monophosphate (dTMP), which then undergoes phosphorylation to deoxythymidine diphosphate (dTDP), then to Deoxythymidine triphosphate (dTTP), and incorporated into DNA by the DNA polymerase (DNA pol). Thymine in tRNA arises post-transcriptionally, by S-adenosylmethionine-dependent methylation of a uridine 5'-monophosphate (UMP) residue in RNA.

Explanation:

Thymidylate synthase is an enzyme involved in de novo DNA synthesis. This enzyme (thymidylate synthase) catalyzes the transfer of the one-carbon group from 5,10-methylene-tetrahydrofolate (5,10-CH2-THF) to deoxyuridine monophosphate (dUMP) and subsequent methylation to produce deoxythymidine monophosphate (dTMP), which is then phosphorylated to deoxythymidine triphosphate (dTTP) by kinases and incorporated into DNA. On the other hand, specific tRNA methylases catalyze the methylation of transference RNA (tRNA) by using S-adenosylmethionine as a methyl donor. Since tRNA methylation is a post-transcriptional modification, this chemical reaction is considered an epitranscriptomic modification on the RNA molecule.

We hope our answers were helpful. Return anytime for more information and answers to any other questions you may have. We hope this was helpful. Please come back whenever you need more information or answers to your queries. Westonci.ca is your trusted source for answers. Visit us again to find more information on diverse topics.