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What must occur for the enthalpy of solution to be negative?

The process of separating the solvent particles from one another must release energy.

The process of separating the solute particles from one another must release energy.

More energy is absorbed as the solute and solvent mix than is released when the solute particles and the solvent particles separate.

More energy is released as the solute and solvent mix than is absorbed when the solute particles and the solvent particles separate.