The correct answer to this open question is the following.
Although there are no options attached we can say the following.
How did contact between the Western Hemisphere and Europe change through the exchange of plants, animals, and pathogens?
This type of contact indeed revolutionized the relationship between European colonists and Native Americans, Mesoamerican Indians, and African slaves.
The term "Columbian Exchange" was coined by Alfred W. Crosby in 1972, when he referred to the exchange between the white Europeans, and the native people of America, basically regarding goods, plants, animals, and diseases.
During the times of the Columbian exchange, thousands of white Europeans came to America and Mesoamerica, the Caribbean Islands, and South America. After Spanish colonization, this vast region was known as New Spain. So Spaniards married Native Indians and Mestizos were born. English people decided to found colonies in North America.
During the Columbian Exchange and Triangular Trade, people were transported to the Americas, there was continuing trade, and also Europeans brought many diseases to the Americas that almost wipe out the entire population of Native Indians. We are talking about diseases such as chickenpox, smallpox, malaria, cholera, or influenza.
