In the U.S., the first federal regulations for human subjects research began in 1981 with the codification of the Common Rule.
The use of humans as subjects for research purposes has been an ongoing issue even to this day. But at the same time, using actual humans as test subjects seems to be how experimentations were done to verify and prove things actually work on human beings.
- Common Rule was a rule of ethics to regulate the use of human subjects for biomedical as well as behavioral research.
- This regulation was codified in 1981, making it the first federal regulation for human subjects in research activities in the United States.
- The Nuremberg Code was also a code for medical practices but codified in 1947.
- Likewise, the Declaration of Helsinki was adopted in 1964 while the Belmont Report was in 1979.
The Common Rule of 1981 became the United States' first federal regulation for the use of human subjects for experimental and research purposes. Thus, the correct answer is the Common Rule.
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