Answer:
Those other problems:
As another example were the politics of colonization. Even though at first only Spain was interested in colonizing the Americas, after a while you basically had skirmishes every time you explored as to whom the land belonged to. Because then England, France, Holland and Portugal were claiming colonies and not all got along very well, in fact attacks by other nations were common during the early days.
One big problem was that they were in fact lost in these new continents. They either relaid on local guides or just gut feelings. Which was catastrophic in the sense that if they got lost; nobody could help them. Many explorers were lost on the conquest of South America. Other tragic examples were Humbolt's and Cabeza de Vaca's expedition on North America. The bottom line is that they weren't prepared or had any idea of what to expect on these new lands.
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