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with regard to enzymes, what can be said to the relationship between the substance and the active site?

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The substrate and the active site both need to fit together perfectly in order for the enzyme to work properly. If their shape is changed, typically through heat or a change in pH, the enzyme will not work.

Answer:

A

Explanation:

One substrate binds specifically to the active site and is changed into products. Enzymes are highly specific to their subsrate. They catalyze a reaction that changes the subsrate into a product.

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