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A researcher found a mutation that resulted in
the PFK enzyme being unable to bind ATP to the
allosteric site. Which of the following best
predicts the effect of the mutation?


Sagot :

In this case, the negative feedback regulation is not possible not occur. In consequence, the enzyme will be active even when glycolysis is not needed.

Negative feedback regulation

Negative feedback happens when a given output is fed back in a way that tends by itself to reduce its fluctuations.

Phosphofructokinase-1 represents the most important enzyme required to carry out glycolysis.

Allosteric regulation refers to the regulatory process by which an enzyme binds an effector molecule at a site different from the active site.

Learn more about negative feedback regulation here:

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