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Answer:
After first exposure to an antigen, it can take about three weeks for antibodies to reach a detectable level. The body will react to disease by creating antibodies and testing their effectiveness against the unknown antigen.
Antibodies are the body's way of fighting off foreign threats. Also known as immunoglobulin, they detect and attack pathogenic bacteria and viruses. These antibodies detect a protein that is unique to the surface of the pathogen called the antigen.
At times, we can see an increase in antibodies for one disease, for example, Lyme disease, in the presence of non-Lyme disease antigens. This is often due to antigenic variation, which is a method used by pathogens to mask their respective antigens. There are also general use antibodies that will increase in reaction to any pathogen.
As with any illness, a patient who receives treatment sooner will fare better than those whose treatment is delayed. This is due to the fact that earlier treatment with antibiotics will allow the body to fight off the infection before the bacteria can reproduce further.
After the first immune response, antigen-specific antibodies will remain for some time to provide the body with "immunity" to the pathogen, while general-purpose antibodies will return to a base value.
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A period comprised of three weeks after the first exposure is required to detect antibodies.
What are immune responses?
Immune responses refer to the reactions (e.g., inflammation) which undergo the human body after exposure to infections caused by pathogens such as bacteria or viruses.
- Lyme disease is a disease generally caused by Borrelia burgdorferi bacteria.
- The significant increase in antibodies to non-Lyme disease antigens can be explained by antigenic variation, which is a natural evolutionary mechanism used by pathogens to infect an organism.
- Patients with Lyme disease who are treated with antibiotics quickly usually react much better than those who are treated later because antibiotics are more efficient to stop infection during the early stages (i.e., before uncontrolled pathogen reproduction).
- Antibodies in Lyme disease antigens do not decrease after the first immune response because this disease can be masked by the bacterial pathogen.
- The control of antibiotic use is fundamental to avoid the emergence of natural resistance, which is a natural evolutionary process caused after pathogen exposure.
In conclusion, a period comprised of three weeks after the first exposure is required to detect antibodies.
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