Read the map.

A map titled The Empire of Alexander the Great. Shading extends from Macedonia and Greece, south into Egypt, east into Ionia, through Media and Persia, ending near the border of India. The shaded areas are bordered by the Black Sea, Caspian Sea, Mediterranean Sea, and Arabian Sea.

How did the location of Alexandria affect Hellenistic culture?

Its location on the sea made it a cultural crossroads.
Its location close to Greece made it an influential city.
Its location introduced Asian culture to the rest of Europe.
Its location isolated it from other cultures in the empire.