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The following events are part of endochondral ossification. In which order do they occur?
• Formation of the primary ossification center
• Osteoclasts break down the spongy bone to create marrow cavity.
• Cells from the perichondrium differentiate into osteoblasts.
• Formation of the secondary ossification centers
• Calcification of matrix surrounding chondrocytes
A.)1,423,5
B.)5,3,1,2,4
C.)1,5,3,4,2
D.)5,3,1,4,2


Sagot :

The order is calcification of matrix  >> cells differentiate into osteoblasts >> formation of the primary ossification >>  osteoclasts break down the spongy bone >> formation of the secondary ossification (5,3,1,2,4). It is a fundamental process.

What are osteoblasts?

Osteoblasts are cells of the bones, which act to generate bone matrix and modulate the process of mineralization of the skeleton.

Endochondral ossification refers to the mechanism through which the cartilaginous bones generate longitudinal growth.

This mechanism (endochondral ossification) is fundamental during fetal/embryo development.

Learn more about endochondral ossification here:

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