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How is the half-life of a radioactive isotope determined?

A. By measuring the time it takes for half the daughter nuclei in a sample to become parent nuclei
B. By measuring the time it takes for all the parent in a sample to become daughter nuclei
C. By measuring the time it takes for all the daughter nuclei in a sample to become parent nuclei
D. By measuring the time it takes for half the parent nuclei in a sample to become daughter nuclei