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Why is an enzyme in a chemical reaction like a lock and key?

A. The active site and the substrate fit perfectly together, and when they do, they unlock the chemical reaction.
B. The non-reactive site and the substrate fit perfectly together, and when they do, they unlock the chemical reaction.
C. None of these
D. The nucleoid and Golgi Apparatus fit perfectly together, and when they do, they unlock the chemical reaction.
E. The active site and the cell membrane fit perfectly together, and when they do, they unlock the chemical reaction.