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You are studying a region of the genome on chromosome 11 that contains several hemoglobin genes and their associated cis-regulatory modules (CRMs). These CRMs are DNA elements where proteins can bind to regulate expression of the hemoglobin genes. These genes are expressed at different times during development. HBB and HBD are expressed in adults, HBG1 and HBG2 are expressed during fetal development, and HBE1 is expressed during embryonic development. GATA1 is a transcription factor expressed in blood cells. What evidence (if any) does not support the hypothesis that CRM B has a function associated with it

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luisvaschetto

Although part of your question is missing, you might be referring to this full question:

You are studying a region of the genome on chromosome 11 that contains several hemoglobin genes and their associated cis-regulatory modules (CRMs). These CRMs are DNA elements where proteins can bind to regulate expression of the hemoglobin genes. These genes are expressed at different times during development. HBB and HBD are expressed in adults, HBG1 and HBG2 are expressed during fetal development, and HBE1 is expressed during embryonic development. GATA1 is a transcription factor expressed in blood cells. What evidence (if any) supports the hypothesis that CRM B has a function associated with it? (Mark all that apply)

  • only coding regions of the genome have a function
  • biochemical evidence
  • genetic evidence
  • evolutionary evidence

The evidence that does not support the hypothesis is genetic evidence because it involves the lack of binding between GATA1 and CRMs.

What is a transcription factor?

A transcription factor is a specific protein that enters in the nucleus of one cell to regulate gene expression.

Transcription factors such as GATA1 are required to bind specific regulatory DNA sequences (e.g., promoters) to activate or inhibit gene expression.

In this case, regulation at different stages of development is likely due to epigenetic factors instead of transcription factor binding.

In conclusion, the evidence that does not support this explanation is genetic evidence.

Learn more about transcription factors here:

https://brainly.com/question/8926797

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