Enzyme inhibitors are either competitive, uncompetitive or non-competitive inhibitors and have different effects on Km and Vmax.
What are enzyme inhibitors?
Enzyme inhibitors are substances which inhibit the catalytic activity of enzymes.
Enzyme inhibitors are classified into three:
- Competitive inhibitors - compete with substrate for enzyme binding site. They have no effect on Vmax but increases Km.
- Uncompetitive inhibitors- bind to the enzyme–substrate complex. They decrease both Vmax and Km.
- Non-competitive inhibitors- bind to another site on the enzyme. They have no effect on Km but Vmax is decreased.
Therefore, the enzyme inhibitors are either competitive, uncompetitive or non-competitive inhibitors and have different effects on Km and Vmax.
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