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Read the article to learn more about the disorders that can occur when there is an irregular number of chromosomes. human chromosomal disorders explain how nondisjunction can lead to aneuploidies.

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In nondisjunction, if members of a pair of homologous chromosomes do not move apart during meiosis I or sister chromatids fail to separate during meiosis II, this means one gamete receives 2 of the same kind of chromosome and if either one of these abnormal gametes unites with a normal one at fertilization, the zygote will also have an abnormal number of particular chromosomes; which is known as aneuploidy.

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