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Sagot :
Apurinic sites in an intact double helix DNA molecule result from the loss of a nucleotide base.
What is an apurinic site?
An apurinic/apyrimidinic/abasic site is a position in a molecule of DNA which lacks any purine or pyrimidine base. These sites are also found in RNA molecules but their frequency is more in DNA molecules.
DNA damage caused by a spontaneous depurination can result in the formation of an abasic site.
In the presence of an abasic site, DNA polymerases cannot function. Thus to maintain the integrity of the genome, these sites need to be repaired.
Two methods to repair are base excision repair and nucleotide excision repair.
Read more about DNA damage, here
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