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Women readily develop lower body fat around the hips and thighs and men readily develop central body fat around the abdomen. This primarily is due to gender differences in the activity of lipoprotein lipase determines this
Lipoprotein lipase (LPL) is a vascular endothelial extracellular enzyme that degrades circulating triglycerides in the circulation. These triglycerides are carried in the bloodstream by very low-density lipoproteins (VLDL) and chylomicrons.
Lipoprotein lipase is essential in the breakdown of fat in the form of triglycerides, which are delivered from numerous organs to the bloodstream by molecules known as lipoproteins.
Although lipoprotein lipase may not be the only determinant of lipid accumulation in adipocytes in obese adults, an increase in lipoprotein lipase activity and expression may aid fat storage and perhaps lead to increased eating.
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