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Many human cells divide a finite number of times before going into permanent arrest, a phenomenon called Hayflick’s Phenomenon, which appears to be caused by the loss of telomeres.
Hayflick limit or Hayflick’s phenomena is defined as the number of times a normal cell population divides before entering the senescence phase.
Hayflick (1961) demonstrated that a population of normal human fetal cells divide in culture between 40 and 60 times before stopping.
This phenomenon is related to telomere length. Repeated mitosis leads to shortening of the telomeres on the DNA of the cell. Telomere shortening in humans eventually makes cell division impossible, and correlates with aging.
Telomeres are irrevocably shortened each time a cell divides. When the telomeres become too short, the cell can no longer divide.
Learn more about Hayflick's phenomenon here:
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