Nonhomologous end joining would be most appropriate for repairing double-stranded DNA breaks.
How are double stranded breaks in DNA repair?
- Homologous recombination and nonhomologous DNA end joining are the two main mechanisms for mending double-strand DNA breaks, which often occur in eukaryotic cells.
- DNA ends that need to be repaired have a different chemistry as a result of the many causes of DSBs.
- The enzymes of the NHEJ pathway display a remarkable level of structural tolerance in the variety of DNA end substrate configurations upon which they may function over the course of NHEJ development.
- The nuclease, polymerases, and ligases of NHEJ are the most versatile and mechanistically adaptable enzymes in each of their classes in vertebrate cells.
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