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Sagot :
Enzymatic and other proteinic activity is limited by pH. 2) Slight deviations from normal pH can shut down metabolic pathways. 3) The structure and function of macromolecules are pH dependent.
How does the pH levels affect enzymes and proteins?
Enzymes, like all proteins, are polypeptidic molecules.
They need to get an accurate tridimensional structure to accomplish their function.
There is a limit of temperature and pH level at which they lose that structure and denaturalize.
pH changes
The most accurate configuration for the best catalytic performance depends on the charge of the lateral chains and the environmental pH.
Enzymes have ionizable chemical groups in the lateral chains of their amino acids.
Depending on the environmental pH, these groups will have a positive, negative, or neutral charge.
There is an optimum pH level at which enzymes get the best configuration to accomplish their functions.
Most enzymes are sensitive to any change in pH, which might drastically affect their activity. So every enzyme has its optimum pH level, and any slight deviations will cause the enzyme denaturalization, hence, its activity loss.
Whenever the enzyme loses its configuration, and hence, its function, the whole pathway in which it is involved is interrupted.
Options 2 and 3 are correct.
- Slight deviations from normal pH can shut down metabolic pathways.
- The structure and function of macromolecules are pH dependent.
You can learn more about enzymes and pH at
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Why is it important to maintain the ph of blood and tissue fluids within normal limits? check all that apply
- Most enzymes require an acidic pH to function properly.
- Slight deviations from normal pH can shut down metabolic pathways.
- The structure and function of macromolecules are pH dependent.
- Hormones require a blood pH of at least 77 to function,
- A drop in blood pH causes dehydration
The pH balance plays an important role in the chemical makeup of the human body.
REASONS :
A pH balance simply means that the acid-base balance in the body is generally maintained. The body needs to stay in homeostasis (a stable state) to function optimally.
1.Slight deviations from normal pH can shut down metabolic pathways.
2. The structure and function of macromolecules are pH dependent.
Learn more about pH balance here:
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