Pyruvate carboxylase and phosphoenolpyruvate carboxykinase catalyze reactions of gluconeogenesis that bypass the reaction of glycolysis that is catalyzed by pyruvate kinase.
The tissues of some organs, including the brain, the eye, and the kidney, use glucose as their primary or only source of metabolic fuel. Glycogen stores become exhausted during a protracted fast or intense exercise, and glucose must be created from scratch to keep blood glucose levels stable. The process through which glucose is created from non-hexose precursors such glycerol, lactate, pyruvate, and glucogenic amino acids is known as gluconeogenesis.
Glycolysis is effectively reversed during glucose synthesis. However, gluconeogenesis makes use of four distinct enzymes to skip the three highly exergonic (and essentially irreversible) phases of glycolysis. The pyruvate carboxylase, PEP carboxykinase, fructose 1,6-bisphosphatase, and glucose 6-phosphatase enzymes are specific to gluconeogenesis. Gluconeogenesis can only take place in particular tissues because these enzymes are not found in all cell types. In humans, the liver and, to a lesser extent, the renal cortex are the primary locations for gluconeogenesis.
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