Mueller et al. created a strain of mice that lacked the receptor that normally responds to a bitter substance called cyx. The mice that did not have this receptor?

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02-08-2022
Biology

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Mueller et al. created a strain of mice that lacked the receptor that normally responds to a bitter substance called cyx. The mice that did not have this receptor?

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tanisharawat014 tanisharawat014 · Answer 1 · 2022-08-15T12:07:54-04:00

Mueller et al. created a strain of mice that lacked the receptor that normally responds to a bitter substance called cyx. the mice without this receptor did not avoid cyx.

What is cyx receptor?

cyclohexamide(cyx) is a toxic antibiotic with a unique chemical structure genrated by the actinomycete, streptomyces griseus,has emerged as a primary focus of studies on mammalian bitter taste.Rats and mice avoid it at concentrations well below the thresholds for most bitter stimuli and T2R G-protein coupled receptors specific for cyx with appropriate sensitivity identified for those species.Like mouse and rat,golden hamsters,Mesocricetus auratus, also detected and rejected micromolar levels of cyx.

the gene for the high affinity cyx receptors is a member of a cluster of 5 orthologous T2R genes that are likely rodent specific ;thus "cyx clade " is found in the mouse,rat and probably hamster, but not in the human or rabbit genome.

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