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The virus that causes rabies travels up nerve cells to the brain and spinal cord. Endosomes cell structures will allow the virus to move through the nerve cells
The main function of endosomes is intracellular sorting. They control the movement of proteins and lipids between the plasma membrane Golgi, the trans-Golgi network (TGN), and vacuoles and lysosomes, among other subcellular compartments in the secretory and endocytic pathway.
Endocytic carrier vesicles move materials destined for lysosomal breakdown from early endosomes to late endosomes. Later, late endosomes merge with transport vesicles carrying lysosomal hydrolases from the trans-Golgi network (TGN), maturing them into lysosomes.
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