yeast cytosine deaminase mutants with increased thermostability impart sensitivity to 5-fluorocytosine

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02-09-2022
Biology

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yeast cytosine deaminase mutants with increased thermostability impart sensitivity to 5-fluorocytosine

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qwchocolate qwchocolate · Answer 1 · 2022-09-11T10:55:04-04:00

So, the sensitivity to 5 - fluorocytosine can be imparted by the mutant yeast cytosine deaminase that has increased thermostability.

Prodrug gene therapy is a technique by which a non-toxic drug is converted into a cytotoxic drug by an enzyme that is produced by transfected tumor cells with a gene. Cytosine deaminase is among the important enzymes that facilitate the production of uracil from cytosine. It also plays a key role in inhibiting the synthesis of DNA and the functioning of RNA by converting 5 FC to 5 FU.

Due to the restricted thermostability of 5- fluorocytosine, cytosine deaminase's different forms have been limited.

In an experiment to study the half-life of yeast cytosine deaminase, cores of the yeast's hydrophobic ends were packed to distance it. An enzyme LCD-D92E was produced that increased the half-life.

So, the sensitivity to 5 - fluorocytosine can be imparted by the mutant yeast cytosine deaminase that has increased thermostability.

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