correlating nuclear morphology and external force with combined atomic force microscopy and light sheet imaging separates roles of chromatin and lamin a/c in nuclear mechanics

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02-09-2022
Biology

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correlating nuclear morphology and external force with combined atomic force microscopy and light sheet imaging separates roles of chromatin and lamin a/c in nuclear mechanics

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snehashish65 snehashish65 · Answer 1 · 2022-09-13T05:28:42-04:00

When nuclei migrate through narrow channels or are compressed by the act of cap, they frequently experience external atomic stress, and the mechanical characteristics of the nuclei control how they deform as a result.

What is Atomic force microscopy?

Atomic force microscopy (AFM) is a method for studying a rigid material's surface all the way down to the atomic level. AFM creates 3-D images of the surface and uses a mechanical probe to magnify surface characteristics up to 100,000,000 times.

Researchers will be able to comprehend the force on nuclei throughout various biological processes according to the proven relationship between particular forms of nuclear morphological change and applied force.

Therefore, atomic force microscopy and light sheet imaging separates roles of chromatin and lamin a/c in nuclear mechanics.

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