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Sagot :
The correct answer is because it had the highest affinity for penicillin-binding proteins 2, 1A, 1B, and 3 in cell-free Escherichia coli W-7 preparations.
CP-65,207 is a new parenteral penem antibiotic with a broad spectrum that includes gram-positive, gram-negative, and anaerobic microorganisms, with MICs less than or equal to 1 microgram/ml for 90% (MIC90s) of the majority of 1,101 clinical pathogens tested. The compound was 10- to 100-fold more active against gram-positive bacteria and anaerobes than cefoxitin and broad-spectrum cephalosporins. For staphylococci, group A streptococci, and Enterococcus faecalis, CP-65,207 was less effective than imipenem. CP-65,207 was 100-fold more active than cefoxitin, 5- to 10-fold more active than broad-spectrum cephalosporins, and 2-fold more active than imipenem against members of the family than imipenem against members of the antimicrobial family.
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