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Sagot :
Answer: Zeb2 controls commitment to both the cDC2 and pDC lineages by inhibiting Id2.
Explanation: Pre-pDCs give rise to plasmacytoid dendritic cells, whereas pre-cDCs, which are lineage-committed, give rise to the two lineages of conventional dendritic cells (cDC1 and cDC2). The formation of pDCs and cDC1s has been linked to a number of transcription factors , but it is uncertain whether TFs are necessary for pre-cDCs to commit to the cDC2 lineage at an early stage. From the pre-pDC and pre-cDC stage on, Zeb2 was expressed, and it was significantly expressed in mature pDCs and cDC2s. Id2 was discovered to be a specific target of Zeb2 by chromatin immunoprecipitation research. We thus deduce that Zeb2 controls commitment to both the cDC2 and pDC lineages by inhibiting Id2.
For more information on transcription factor refer to this link: https://brainly.com/question/25766207
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