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Sagot :
The discussion of irf4 transcription-factor-dependent cd103 cd11b dendritic cells drive mucosal t helper 17 cell differentiation is given in the below paragraph-
The predominant migratory DC population in the small intestinal lamina propria (SI-LP) is composed of CD103(+)CD11b(+) dendritic cells (DCs), although it is yet unknown what these cells do in vivo. Here, we show that intestine CD103(+)CD11b(+) DC survival required IRF4 to function (IRF4). Mice with a DC loss in Irf4 showed decreased numbers of helper T 17 (Th17) cells that secrete IL-17 in the gastrointestinal tract and failed to support Th17 cell development in draining mesenteric lymph nodes (MLN) after immunization. Both CD103(+)CD11b(+) MLN DCs and DC-derived IL-6 were selectively decreased in the latter. Immunized Il6(-/-) mice were unable to sustain Th17 cell development in MLN in vivo, although CD103(+)CD11b(+) MLN DCs were able to do so in vitro.
Findings collectively point to a critical function for IRF4-dependent, IL-6-producing CD103(+)CD11b(+) DCs in intestinal Th17 cell development.
What is cell differentiation?
The transformation of a stem cell from one type to a differentiated one is known as cellular differentiation. Usually, the cell transforms into a more focused kind. Multiple instances of differentiation take place while a multicellular creature develops from a straightforward zygote to a complex system of tissues and cell types.
As adult stem cells divide and produce completely differentiated daughter cells during tissue repair and normal cell turnover, differentiation continues throughout maturity. In response to antigen exposure, some differentiation takes place. Size, shape, membrane potential, metabolic activity, and signal responsiveness of a cell all undergo significant changes during differentiation.
To learn more about cell differentiation with the help of given link:
https://brainly.com/question/20242601
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