It may be inferred that Roderick's unusual affliction is Fear. See the explanation of this below.
One of Poe's character doppelgangers, Roderick is one of the two remaining Usher family members in "The Fall of the House of Usher." While Madeline, Roderick's sickly and bedridden twin sister, is an intelligent and bookish person.
The conclusion that Roderick dies of dread may be inferred from the closing scene.
He collapses to the ground like a corpse as Madeline races toward him, too afraid to continue living.
It's even conceivable that Madeline is only a physical representation of Roderick's concerns.
Roderick claims that Madeline has a cataleptic condition, which has gradually reduced her mobility.
The narrator observes his sister passing through a faraway area of the home while Roderick describes his sister's ailment.
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