The false statement about GPCRs is that (a) the different classes of GPCR ligands (proteins, amino acid derivatives, or fatty acids) bind to receptors with different numbers of transmembrane domains.
GPCRs are the transmembrane receptors that cross the membrane seven times. These are also known as serpentine receptors. These are the largest family of transmembrane receptors. The G-proteins of these receptors can be monomeric or trimeric. The trimeric G proteins consists of three subunit: α, β and γ.
Transmembrane domains are the part of the transmembrane proteins that cross the plasma membrane. The transmembrane domain is mostly α-helical in structure, although β-barrels are also present in rare cases.
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