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Sagot :
The nucleophile of the first step of the spliceosome-mediated pre-mRNA splicing is the: A. 2' hydroxyl of the branch to point adenosine.
The spliceosome is the large RNA-protein that complex that catalyses the removal of the introns from the nuclear pre-mRNA. A wide range of the biochemical and the genetical studies shows that the spliceosome was comprises three major form of RNA-protein subunits, the U1, U2 and [U4/U6. Most of the splicing occurs in between the exons on the single the RNA transcript, but they occasionally trans-splicing occurs, in which the exons on the different pre-mRNAs are they ligated together. The splicing is process that occurs in the cellular machines called as spliceosomes, in which the snRNPs are to be found along with additional proteins.
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