Because oral drug delivery is the most practical and economical route of administration, the majority of medications are given this way.
Although oral delivery seems to be the simplest method for medication administration, it is actually one of the trickiest. Although the GI tract has a huge surface area for absorption, the GI epithelium is only made to allow molecules with a particular set of physicochemical qualities to pass through. Because of this, the absorption of various medications varies greatly; some may absorb more than 90% of their substance while others may absorb less than 10%. Numerous approaches have been developed, with varying degrees of success, to increase the oral absorption of low bioavailable medications. A solid grasp of the GI physiology and the process of drug absorption is essential for creating a successful strategy. The GI tract has various important variances, all of which have a considerable effect on how well drugs are absorbed.
Thus, Consequently, a thorough analysis of the methods for enhancing oral drug absorption with a focus on the cellular and molecular mechanisms is required.
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