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Activated g protein-coupled receptors can? a. bind gtp b. open an ion channel c. raise cytosolic calcium d. a and b are correct e. a, b and c are correct

Sagot :

bharathparasad577

The correct statements are:

A bind GTP

B open an ion channel and

C raise cytosolic calcium

  • The majority of cellular responses to environmental inputs are mediated by G protein-coupled receptors (GPCRs).
  • Upon ligand activation of the receptor, it binds to heterotrimeric G protein partners, facilitates the exchange of GTP to GDP, cleaves the G protein into subunits, and mediates downstream signaling.
  • Arrestins also enable GPCRs to activate multiple signaling pathways. Small modifications at the ligand-binding or orthosteric sites are amplified to produce larger conformational changes, translocating the GPCR to its active state.
  • Structures, spectroscopic data, and computer simulations of various GPCRs crystallized in active and inactive states provide molecular knowledge of allosteric coupling between ligand binding and G-protein or arrestin interactions. Instead of being adjusted, the connection is loose.

Therefore, option e. is correct.

Learn more about GPCR:

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