Activated g protein-coupled receptors can? a. bind gtp b. open an ion channel c. raise cytosolic calcium d. a and b are correct e. a, b and c are correct

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07-09-2022
Biology

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Activated g protein-coupled receptors can? a. bind gtp b. open an ion channel c. raise cytosolic calcium d. a and b are correct e. a, b and c are correct

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bharathparasad577 bharathparasad577 · Answer 1 · 2022-09-12T02:44:32-04:00

The correct statements are:

A bind GTP

B open an ion channel and

C raise cytosolic calcium

The majority of cellular responses to environmental inputs are mediated by G protein-coupled receptors (GPCRs).
Upon ligand activation of the receptor, it binds to heterotrimeric G protein partners, facilitates the exchange of GTP to GDP, cleaves the G protein into subunits, and mediates downstream signaling.
Arrestins also enable GPCRs to activate multiple signaling pathways. Small modifications at the ligand-binding or orthosteric sites are amplified to produce larger conformational changes, translocating the GPCR to its active state.
Structures, spectroscopic data, and computer simulations of various GPCRs crystallized in active and inactive states provide molecular knowledge of allosteric coupling between ligand binding and G-protein or arrestin interactions. Instead of being adjusted, the connection is loose.

Therefore, option e. is correct.

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