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embrane symmetry/asymmetry a. explain how the following four facts relate to each other. fact 1: in artificial lipid bilayers, lipid molecules do not cross over (flip flop) from one monolayer to the other. fact 2: the membrane of the endoplasmic reticulum is symmetrical with respect to its lipid composition, yet all lipids are initially added to the cytosolic monolayer. fact 3: transport vesicles from the er supply membrane to the plasma membrane. fact 4: plasma membranes are asymmetrical with respect to their lipid composition.