In this program, you are provided with phenotype counts of
F1 and F2 offspring at two research institutes.
The data are generated from an initial parental cross of elegant cranes,
whose genetics are identical to fruit flies, with the exception that they
look like crane birds. The cranes for each institute come from the same original source.
For each institute, in the parental generation (P0), one parent displays
the wild-type (WT) phenotype and one the disease phenotype.
The WT parent always has a homozygous genotype, and whether the disease
parent has a homozygous genotype depends on which scenario describes data
in the F1 generation. The possibilities for F1 individuals are:
(a) All individuals are disease;
(b) All individuals are wild-type;
(c) There are disease and wild-type individuals.
When both disease and WT individuals (item (c)) are available in the F1 generation
then you should use the F1 cross, (disease) X WT.
For each institute, there are three possible modes of inheritance that underlie
the generation of the data. All are monogenic. They are:
(i) Autosomal Recessive.
(ii) Homozygous Lethal Dominant.
(iii) Autosomal Dominant.
In this assignment you are provided with computer-generated data
given one of the modes of inheritance (i) - (iii) above.
Your task is two-fold:
(1) To perform a chi-square goodness of fit test on the F2 observed data
at each research institute and report the ChiSquare statistic and
thecorresponding p-value, under the specification that the mode of
inheritance is Autosomal Dominant (AD) for both institutes, and:
(2) Apply the Fisher Combined P-value Test to the p-values from each
research institute and decide whether you reject or do not reject
the null hypothesis that the mode of inheritance for the crane diease
at each research institute is Autosomal Dominant.
RESEARCH INSTITUTE 01
F1 DATA
Phenotype
Disease Wild-Type
37 0
F2 DATA
Phenotype
Disease Wild-Type
27 10
RESEARCH INSTITUTE 02
F1 DATA
Phenotype
Disease Wild-Type
33 0
F2 DATA
Phenotype
Disease Wild-Type
25 8
