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Sagot :
A deficiency of pancreatic exocrine secretion can result in a decreased formation of bile-salt micelles.
The pancreas produces bicarbonate and digestive enzymes (pancreatic lipase and colipase, enzymes that degrade dietary lipids). Bicarbonate neutralizes stomach acid. The decreased production of bicarbonate will lead to a decrease of intestinal pH. Low levels of pancreatic lipase results in the decreased digestion of dietary triacylglycerols, this will lead to the formation of fewer bile salt micelles. The reduced pH will also interfere with the bile salts to effectively form micelles. Intestinal cells will have less substrate for chylomicron formation, and less fat soluble vitamins will be absorbed. Therefore, more dietary fat will be excreted in the feces. Thus, deficiency of pancreatic exocrine secretion can result in a decreased formation of bile-salt micelles.
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