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Sagot :
Pilocarpine and other parasympathomimetic medicines constrict the pupil and "pull" on the trabecular meshwork, increasing the flow of aqueous out of the eye.
What is pilocarpine's mechanism of action in the treatment of glaucoma?
Pilocarpine contracts the ciliary muscle in open-angle glaucoma, increasing the outflow of aqueous humour and lowering intraocular pressure. Pilocarpine-induced miosis in closed-angle glaucoma widens the angle of the anterior chamber of the eye, allowing aqueous fluid to leave.
Pilocarpine acts on a subtype of muscarinic receptor (M3) located on the iris sphincter muscle, causing the muscle to contract and cause miosis. This effect is crucial in the treatment of various angle-closure glaucomas in the short term.
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