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Ras activates the MAP kinase signal transduction pathway.
The Ras/Raf/MAPK pathway is likely the most well-studied signaling pathway in cell biology. This pathway transports signals from the extracellular milieu to the cell nucleus, where specific genes are activated to promote cell growth, division, and differentiation.
Ras activates several pathways, including the RAF-MEK-ERK/MAPK cascade, which sends signals downstream and causes the transcription of genes involved in the control of various cellular mechanisms.
The binding of extracellular mitogen to a cell surface receptor initiates the MAPK/ERK pathway. This allows a Ras protein (a Small GTPase) to exchange a GDP molecule for a GTP molecule, flipping the pathway's "on/off switch."
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