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HLA-incompatible organ transplant is the most susceptible to rejection and has the best graft survival rates when the organ is obtained from hla-identical, abo-compatible siblings
A gene complex called human leucocyte antigen (HLA) is responsible for producing the MHC proteins in people. The control of the human immune system is carried out by these cell-surface proteins. The HLA is a crucial factor in organ transplant rejection because it causes the body to create antibodies when the organ from the donor is recognized as non-self.
In identical twins, HLA is identical. Therefore, twins, siblings with some similarity, followed by a parent with some similarity, are the top choices for transplantation. If a family member cannot donate, an unrelated donor will be given the least preference. Therefore, Twin>Sibling>Parent>Unrelated donor is the right order of chances of successful transplantation.
Hence, chances of HLA-incompatible organ transplant success lies in closeness of patient to donor.
To know more about MHC proteins.
https://brainly.com/question/12958850
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