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Numerous defense systems exist in cells to stop mutations, or long-lasting alterations in DNA sequence.
Numerous defense systems exist in cells to stop mutations, or long-lasting alterations in DNA sequence. Most DNA polymerases "check their work" during DNA synthesis, correcting the majority of mis paired bases in a procedure known as proofreading. Any mismatched bases that are still present after DNA synthesis can be found and fixed through a procedure known as mismatch repair.
Different processes, such as chemical reversal, excision repair, and double-strand break repair, can be used to fix damaged DNA.
In fact, replication mistakes and DNA damage occur often in the cells of our bodies. However, they typically don't result in cancer or even mutations. That's because DNA repair and proofreading systems typically identify them and fix them. The cell will also go through programmed cell death (apoptosis), which prevents the flawed DNA from being passed on, if the damage cannot be repaired.
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