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Sagot :
Additionally, these sickle cells develop a hard and sticky coating that can hinder or delay blood flow.
How can red blood cells contribute to sickle cell disease?
Red blood cells often have a disc shape and are malleable enough to pass readily through blood vessels. Your red blood cells are crescent- or "sickle"-shaped if you have sickle cell disease. These cells might restrict blood flow to the rest of your body since they are stiff and difficult to move.
What is the RBC morphology of sickle cell disease patients?
Hemoglobin polymerization at low oxygen saturation of the blood causes the relatively stiff hemoglobin chains to distort, giving sickle cells their distinctive morphology.
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