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Sagot :
The oxidative decarboxylation of -ketoglutarate to succinyl coenzyme A is catalyzed by the -ketoglutarate dehydrogenase complex (ODHC) (succinyl-CoA).
What kind of reaction is catalyzed by alpha-ketoglutarate dehydrogenase?
A tightly controlled enzyme called alpha-ketoglutarate dehydrogenase (-KGDH) may control the metabolic flow through the Krebs cycle. It directly creates NADH and catalyzes the conversion of -ketoglutarate to succinyl-CoA, supplying the respiratory chain with electrons.
Does alpha-ketoglutarate dehydrogenase get inhibited by succinyl-CoA?
The -ketoglutarate dehydrogenase complex does not have a sophisticated regulation system comprising a kinase and a phosphatase, in contrast to the pyruvate dehydrogenase complex. High ratios of ATP/ADP, succinyl-CoA/CoASH, and NADH/NAD+, on the other hand, inhibit activity while Ca2+ stimulates it.
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