Welcome to Westonci.ca, your go-to destination for finding answers to all your questions. Join our expert community today! Our platform offers a seamless experience for finding reliable answers from a network of knowledgeable professionals. Get immediate and reliable solutions to your questions from a community of experienced professionals on our platform.
Sagot :
The rate-determining stage in cholesterol production is the conversion of HMG-CoA by HMG-CoA reductase to mevalonate.
Compounds that are successful at lowering serum cholesterol levels target the enzyme HMG-CoA reductase (HMGR).
What is cholesterol synthesis?
Beginning with acetyl-CoA, which is mostly produced from an oxidation event in the mitochondria, the biosynthesis of cholesterol typically occurs in the endoplasmic reticulum of hepatic cells. Acetyl-CoA synthetase can also produce acetyl-CoA via the cytoplasmic oxidation of ethanol.
In a multistep, intricate process, 3-hydroxy-methylglutaryl-CoA reductase (HMG-CoA-R) mediates the rate-limiting stage that catalyzes the conversion of HMG-CoA to mevalonic acid, which is how cholesterol produced from acetyl-CoA.
In both healthy tissues and tumors, both the concentration of cholesterol and the rate of cholesterol biosynthesis are higher. Inhibiting cholesterol biosynthesis prevents cell development, suggesting a connection between cholesterol and DNA synthetic pathways. Cholesterol biosynthesis occurs far earlier than DNA synthesis.
To learn more about cholesterol synthesis Please visit the below link.
https://brainly.com/question/29708076
#SPJ4
We hope you found what you were looking for. Feel free to revisit us for more answers and updated information. Thanks for using our service. We're always here to provide accurate and up-to-date answers to all your queries. Thank you for visiting Westonci.ca. Stay informed by coming back for more detailed answers.
