Vidarabine most likely causes itching and burning in the patient's eyelids as a side effect.
People usually get ocular herpes virus by touching a cold sore and then touching their eyes with a contaminated finger. Once infected, the virus stays in the body for life. Ocular herpes tends to infect the cornea, causing inflammation, eye redness, tearing, and, rarely, blindness.
The use of vidarabine has been replaced by acyclovir due to its lower solubility and toxicity. No longer available as an intravenous dosage form. However, vidarabine should be historically recognized as the first antiviral agent approved for systemic therapy in 1977.
In vitro, vidarabine triphosphate halts herpesvirus DNA replication by incorporating into DNA strands and preventing the formation of base-to-base phosphodiester bridges and ultimately resulting the destabilization of DNA strands of virus.
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