All of the following are examples of how tumors or the microenvironment in which they develop suppress immune responses except.a. induction of T- cell anergyb. peptide splicing of self-proteinsc. cleavage of MIC glycoproteins from tumor-cell surfacesd. TGF- beta-induced recruitment of regulatory T cellse. release of TGF-P and IL-10 by regulatory T cells

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05-12-2022
Biology

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All of the following are examples of how tumors or the microenvironment in which they develop suppress immune responses except.a. induction of T- cell anergyb. peptide splicing of self-proteinsc. cleavage of MIC glycoproteins from tumor-cell surfacesd. TGF- beta-induced recruitment of regulatory T cellse. release of TGF-P and IL-10 by regulatory T cells

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abhinavjh321 abhinavjh321 · Answer 1 · 2022-12-09T02:28:12-05:00

Examples of how tumors or the milieu in which they originate inhibit immune responses include peptide splicing of self proteins.

MHC molecules present tumor rejection antigens, which are peptides of tumor-cell proteins, to T lymphocytes. Because these peptides are not present on the surface of normal cells, at least not in quantities that allow T cells to recognize them, they can serve as targets for a tumor-specific T-cell response. There are six distinct groups of tumor rejection antigens. The antigens in the first group are only specific to tumors. These antigens are the product of gene rearrangements or point mutations, which frequently occur as a result of the oncogenesis process.

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