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Sagot :
An amino acid substitution away from the active region has no effect on the enzyme's substrate selectivity.
If the enzyme changes shape, the active site may no longer bind to the right substrate, resulting in a slower rate of reaction. Temperature and pH fluctuations will ultimately cause enzymes to denature.
The active site and substrate selectivity of an enzyme can be altered by modifying the structure of the enzyme's amino acids.
This is because the changed amino acid codes for the production of a different protein (an enzyme is a protein).
Because this protein has a changed 3D structure and shape, the active site, where the substrate should bind, no longer fits.
Learn more about to amino acid visit here;
https://brainly.com/question/28409615
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