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Epidemics like smallpox often spread rapidly and wiped out entire native tribes. Why weren’t these diseases as fatal for the Spanish? A) The Spanish had vaccinations that made them completely immune to these diseases. B) The Spanish sent infected men back to Spain to contain the disease from spreading. C) The Spanish had doctors whose cures were more effective than native medicine men. D) The Spanish had developed antibodies over time that helped them resist these diseases. E) The Spanish avoided all contact with the villages that were infected by these diseases.

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The answer is D, all the Europeans had gotten smallpox before so eventaully they passed down the anibodies for it from generation to generation. The Native Americans never got the chickenpox until the Spanish came, and so they did not have the anti-bodies to fight back against it.