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Genetic analysis of individuals with Acute Myeloid Leukaemia (AML) frequently reveals numerous chromosomal abnormalities. Normally these cells should be removed before they present any problem, but in AML patients this does not happen.
The protein responsible for detecting these chromosomal rearrangements is P53 which is normally active during G1 PHASE; In some AML patients, you would reasonably suspect cytoplasmic cytochrome C levels to be ?

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